• Home
  • Fair Use Disclaimer
  • Terms and Conditions
  • Social Media Disclaimer
  • Privacy Policy
  • Medical Disclaimer
  • FTC Compliance
  • Earnings Disclaimer
  • DMCA Compliance
  • Copyright Notice
  • Anti-Spam Policy
ParentingHere.com
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS

    Myself Again: The PARENTS Postpartum Survival Guide

    When Should I Tell My Employer I’m Pregnant?

    Double VIP passes available to a Q&A Morning Tea with Pinky – Newborn Baby

    Pregnancy Calendar – Week 34

    Why World Breastfeeding Week is So Important – Newborn Baby

    Pregnancy Calendar – Week 35

    How to use a silicone breast milk collector (and why you would want to) – Newborn Baby

    Pregnancy Calendar – Week 36

    How to deal with postpartum haemorrhoids – Newborn Baby

  • PREGNANCY

    Target Baby Registry Review – Baby Chick

    5 ways to manage labour pain amid Canada’s epidural shortage

    How to Help a Mom Who Has Experienced Loss

    100 Mother-Daughter Quotes – Baby Chick

    Things People Say to Moms But Never to Dads

    Overlooked Safe Sleep Practices that Shouldn’t Be Ignored

    A Good SAHM Routine for Moms with Littles

    Baby Loungers and Sleep: Pros & Cons

    20 Things I Thought Mattered Before Having Kids

  • BABY CARE

    Unique Baby Strollers To Fit Every Family’s Unique Lifestyle

    Why Am I Struggling to Enjoy Motherhood? — The Baby Cubby

    Everything You Need To Know About Stroller Tires 2022

    The Best Disney Stroller Tag To Set Your Ride Apart!

    How to Let Your Kids Know They Matter More Than Your Work — The Baby Cubby

    The Importance Of Home Security System In San Antonio, TX

    Nuna TRVL Stroller Unboxing and Assembly — The Baby Cubby

    Top Dangerous Stroller Mistakes To Avoid For Babies’ Safety

    A Guide to Freezer Meals Plus 3 Easy Recipes — The Baby Cubby

  • TODDLERS

    Can a kid’s penis really get trapped in swimsuit mesh?

    This is actually how much sleep kindergarten kids need

    30 things your tween should know how to do

    24 teen movies on Netflix Canada to watch as a family

    How to deal when you hear “I’m telling” more than you’d like

    Why it used to take hours to get my kids to sleep

    18 of the best sandals for kids to rock all summer long

    I saved a drowning toddler—and here’s what I learned about pool safety

    When will the COVID vaccine for kids under 5 be available?

  • TEENS

    Rolling Admissions: Never Underestimate the Power of an ‘Early Win’

    18 Best Backpacks for Teen Girls in High School and College

    College President has 5 Pieces of Advice to the Class of 2026

    50 Quotes About Raising Daughters That Will Warm Your Heart

    Are You Wondering How to Use a 529 College Savings Plan?

    Parents Should Do Their Best to Avoid ‘We Parenting’

    My Teen Thinks I’m the “Only Mom” and I’m Okay with That

    The Social Media App Every Parent Needs to Know About But Has Never Heard Of

    If My Teens Are Staying Home Then So Am I

  • HEALTH CARE

    Novel targeted therapy may be an effective treatment option for neuroblastoma

    Women and young children hit harder by COVID-19 restrictions

    Shared decision-making training program for nurses to support Down syndrome screening decisions

    Prenatal opioid exposure may cause long-term neurological or behavioral effects later in a child’s life

    Insufficient sleep could have long-lasting impact on the neurocognitive development of pre-teens

    What the polio case in New York tells us about the end of polio

    Vitamin A supplementation is missed by two in five children in India, analysis finds

    Children strongly bonded to pets during COVID experienced more anxiety

    Novel algorithm identifies adverse drug events across the seven pediatric development stages

  • ACTIVITIES & CRAFTS

    Homemade Glittery Unicorn Snot Slime Recipe

    Amelia Island with Kids: 25 Best Things To Do in Fernandina Beach and Amelia Island, Florida | MommyPoppins

    Free Letter Z Worksheets For Preschool & Kindergarten

    Visiting Farmington River Tubing in New Hartford | MommyPoppins

    Gross & Cool Slimey Green Frog Slime Recipe

    Keep Cool in Houston: Top Beaches, Swimming Lakes, Splash Pads, and AC Spots | MommyPoppins

    Amazon Has The Cutest Lunch Boxes for Kids and I Want Them All

    Keep Cool in a Heat Wave in Chicago: Top Beaches, Swimming Lakes, Splash Pads, and AC Spots | MommyPoppins

    Free Letter X Worksheets For Preschool & Kindergarten

  • Contact
  • About
No Result
View All Result
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS

    Myself Again: The PARENTS Postpartum Survival Guide

    When Should I Tell My Employer I’m Pregnant?

    Double VIP passes available to a Q&A Morning Tea with Pinky – Newborn Baby

    Pregnancy Calendar – Week 34

    Why World Breastfeeding Week is So Important – Newborn Baby

    Pregnancy Calendar – Week 35

    How to use a silicone breast milk collector (and why you would want to) – Newborn Baby

    Pregnancy Calendar – Week 36

    How to deal with postpartum haemorrhoids – Newborn Baby

  • PREGNANCY

    Target Baby Registry Review – Baby Chick

    5 ways to manage labour pain amid Canada’s epidural shortage

    How to Help a Mom Who Has Experienced Loss

    100 Mother-Daughter Quotes – Baby Chick

    Things People Say to Moms But Never to Dads

    Overlooked Safe Sleep Practices that Shouldn’t Be Ignored

    A Good SAHM Routine for Moms with Littles

    Baby Loungers and Sleep: Pros & Cons

    20 Things I Thought Mattered Before Having Kids

  • BABY CARE

    Unique Baby Strollers To Fit Every Family’s Unique Lifestyle

    Why Am I Struggling to Enjoy Motherhood? — The Baby Cubby

    Everything You Need To Know About Stroller Tires 2022

    The Best Disney Stroller Tag To Set Your Ride Apart!

    How to Let Your Kids Know They Matter More Than Your Work — The Baby Cubby

    The Importance Of Home Security System In San Antonio, TX

    Nuna TRVL Stroller Unboxing and Assembly — The Baby Cubby

    Top Dangerous Stroller Mistakes To Avoid For Babies’ Safety

    A Guide to Freezer Meals Plus 3 Easy Recipes — The Baby Cubby

  • TODDLERS

    Can a kid’s penis really get trapped in swimsuit mesh?

    This is actually how much sleep kindergarten kids need

    30 things your tween should know how to do

    24 teen movies on Netflix Canada to watch as a family

    How to deal when you hear “I’m telling” more than you’d like

    Why it used to take hours to get my kids to sleep

    18 of the best sandals for kids to rock all summer long

    I saved a drowning toddler—and here’s what I learned about pool safety

    When will the COVID vaccine for kids under 5 be available?

  • TEENS

    Rolling Admissions: Never Underestimate the Power of an ‘Early Win’

    18 Best Backpacks for Teen Girls in High School and College

    College President has 5 Pieces of Advice to the Class of 2026

    50 Quotes About Raising Daughters That Will Warm Your Heart

    Are You Wondering How to Use a 529 College Savings Plan?

    Parents Should Do Their Best to Avoid ‘We Parenting’

    My Teen Thinks I’m the “Only Mom” and I’m Okay with That

    The Social Media App Every Parent Needs to Know About But Has Never Heard Of

    If My Teens Are Staying Home Then So Am I

  • HEALTH CARE

    Novel targeted therapy may be an effective treatment option for neuroblastoma

    Women and young children hit harder by COVID-19 restrictions

    Shared decision-making training program for nurses to support Down syndrome screening decisions

    Prenatal opioid exposure may cause long-term neurological or behavioral effects later in a child’s life

    Insufficient sleep could have long-lasting impact on the neurocognitive development of pre-teens

    What the polio case in New York tells us about the end of polio

    Vitamin A supplementation is missed by two in five children in India, analysis finds

    Children strongly bonded to pets during COVID experienced more anxiety

    Novel algorithm identifies adverse drug events across the seven pediatric development stages

  • ACTIVITIES & CRAFTS

    Homemade Glittery Unicorn Snot Slime Recipe

    Amelia Island with Kids: 25 Best Things To Do in Fernandina Beach and Amelia Island, Florida | MommyPoppins

    Free Letter Z Worksheets For Preschool & Kindergarten

    Visiting Farmington River Tubing in New Hartford | MommyPoppins

    Gross & Cool Slimey Green Frog Slime Recipe

    Keep Cool in Houston: Top Beaches, Swimming Lakes, Splash Pads, and AC Spots | MommyPoppins

    Amazon Has The Cutest Lunch Boxes for Kids and I Want Them All

    Keep Cool in a Heat Wave in Chicago: Top Beaches, Swimming Lakes, Splash Pads, and AC Spots | MommyPoppins

    Free Letter X Worksheets For Preschool & Kindergarten

  • Contact
  • About
No Result
View All Result
ParentingHere.com
No Result
View All Result
Home HEALTH CARE

Novel targeted therapy may be an effective treatment option for neuroblastoma

by admin
July 31, 2022
in HEALTH CARE



New research from VCU Massey Cancer Center -; published Thursday in Cell Reports -; demonstrated that a novel targeted therapy could be an effective treatment option for a deadly pediatric cancer known as neuroblastoma.

Neuroblastoma is a type of cancer that develops in nerve tissue, most commonly in the glands around the kidneys. Despite multiple medical advancements that have improved outcomes for the disease, high-risk neuroblastoma remains responsible for the most cancer-related deaths in children five years and younger.

Previous research has demonstrated that the activation of a specific group of proteins -; MEK/ERK -; helps neuroblastoma cells survive and grow. However, a class of drugs used to prohibit the function of these proteins called MEK inhibitors have proven ineffective in treating the disease because high doses are associated with a substantial level of toxicity.

“Breakthroughs significantly altering the fate of high-risk neuroblastomas have been elusive,” said study author Anthony Faber, Ph.D., co-leader of the Developmental Therapeutics research program and Natalie N. and John R. Congdon, Sr. Endowed Chair in Cancer Research at VCU Massey Cancer Center.

To address the lack of effective treatment options for neuroblastoma, Faber’s laboratory along with his collaborators performed high-throughput drug screening with SHP099. This compound belongs to a new class of drugs that target and block an enzyme called SHP2, which is along the same genetic pathway as MEK/ERK.

High-throughput screening is an important method in drug discovery and design that allows researchers to automate thousands to millions of tests on chemical or biological compounds.

Repeatedly, Faber and his research team found that neuroblastoma tumors in mice were sensitive to SHP099, and the tumors shrank considerably in some of the models. SHP099 had a particularly effective impact in tumor cells that had limited or no expression of the neurofibromin 1 (NF1) protein. Additionally, they determined that NF1 expression is much lower in advanced or relapsed neuroblastoma cells, and the protein is more readily deactivated in high-risk neuroblastoma.

We found variable yet consistently positive effects across all models of low NF1, high-risk neuroblastoma, revealing a new drug target in relapsed disease.”


Anthony Faber, Ph.D., associate professor, Philips Institute for Oral Health Research, VCU School of Dentistry

Faber said one of the most important findings in the study -; made by first authors Jinyang Cai, Ph.D., and Sheeba Jacob, Ph.D., -; was that SHP2 inhibitors were ineffective at blocking the function of MEK/ERK in healthy cells and therefore were not toxic to them.

“These findings suggest that, unlike MEK inhibitors, SHP2 inhibitors may be dosed high enough to inhibit MEK/ERK signaling in neuroblastoma tumors,” said Faber, who credited the high efficiency and capabilities of the Cancer Mouse Models Core at Massey for allowing his team to comprehensively test SHP099.

As there are a large number of SHP2 inhibitors now in clinical testing, Faber will work with collaborator John Glod, M.D., Ph.D., to hopefully bring one of these inhibitors into clinical testing at the National Cancer Institute. Currently, Faber’s group is also planning to test SHP2 inhibitors in combination with anti-GD2 therapy, an approved immunotherapy for neuroblastoma.

In addition to neuroblastoma, Faber’s team also found SHP099 to be effective in head and neck squamous cell carcinoma (HNSCC). Separate findings will be published soon, and the team is planning further testing of a combination therapy in HNSCC with SHP2 and EGFR inhibitors.

Source:

Virginia Commonwealth University

Journal reference:

Cai, J., et al. (2022) High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition. Cell Reports. doi.org/10.1016/j.celrep.2022.111095.



Original Source Link

Previous Post

When Should I Tell My Employer I’m Pregnant?

Next Post

Homemade Glittery Unicorn Snot Slime Recipe

Related Posts

HEALTH CARE

Women and young children hit harder by COVID-19 restrictions

July 30, 2022
HEALTH CARE

Shared decision-making training program for nurses to support Down syndrome screening decisions

July 30, 2022
HEALTH CARE

Prenatal opioid exposure may cause long-term neurological or behavioral effects later in a child’s life

July 30, 2022
HEALTH CARE

Insufficient sleep could have long-lasting impact on the neurocognitive development of pre-teens

July 30, 2022
HEALTH CARE

What the polio case in New York tells us about the end of polio

July 29, 2022
HEALTH CARE

Vitamin A supplementation is missed by two in five children in India, analysis finds

July 29, 2022
Next Post

Homemade Glittery Unicorn Snot Slime Recipe

Rolling Admissions: Never Underestimate the Power of an ‘Early Win’

Myself Again: The PARENTS Postpartum Survival Guide

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recommended

I Know I’m Not Supposed to Be My Teen’s Friend, But Sometimes That’s Exactly What He Needs

6 days ago

Gross & Cool Slimey Green Frog Slime Recipe

1 day ago

You Can Book A Stay In A Dolly Parton-Themed RV and I’m Packing My Bags Kids Activities Blog

4 days ago

Homemade Glittery Unicorn Snot Slime Recipe

3 hours ago

17 Fabulously Fun Weekend Children Activities Kids Activities Blog

3 days ago

My Teen Thinks I’m the “Only Mom” and I’m Okay with That

3 days ago

Organized sports help kids to develop the “grit” for overcoming challenges as adults

4 days ago

Categories

  • ACTIVITIES & CRAFTS (348)
  • BABY CARE (153)
  • HEALTH CARE (283)
  • PARENTING TIPS (306)
  • PREGNANCY (160)
  • TEENS (258)
  • TODDLERS (35)

Popular Posts

50+ Roaringly Fun Dinosaur Crafts & Activities For Kids

2 months ago

The Social Media App Every Parent Needs to Know About But Has Never Heard Of

3 days ago

Study investigates consumer product-related traumatic brain injuries among school-aged children

2 weeks ago

22 Adorable Maternity Photo Ideas

3 months ago

A couple’s quest for autism treatment for their son hits repeated obstacles

1 week ago

Evidence COVID in pregnancy can affect offspring’s neurodevelopment

2 months ago

200 Baby Girl Names That Start With O

5 months ago

Archives

  • July 2022 (481)
  • June 2022 (478)
  • May 2022 (415)
  • April 2022 (53)
  • March 2022 (92)
  • February 2022 (24)

Reader's Choices

Free Letter X Worksheets For Preschool & Kindergarten

by admin
July 29, 2022

...

Recurrent first trimester pregnancy loss – Newborn Baby

by admin
July 20, 2022

...

How to dress for your first trimester, according to a fashion editor

by admin
July 23, 2022

...

Here’s how to hate a beach day with kids a bit less

by admin
July 28, 2022

...

Editor's Picks

My Teen Thinks I’m the “Only Mom” and I’m Okay with That

by admin
July 28, 2022

...

Teen Birthday Party Ideas in Houston: 10 Cool Party Places for Teens and Tweens | MommyPoppins

by admin
July 25, 2022

...

Why World Breastfeeding Week is So Important – Newborn Baby

by admin
July 30, 2022

...

Fewer than half of autistic children receive intervention services before 36 months of age

by admin
July 28, 2022

...

Popular Posts

Pregnancy Calendar – Week 25

by admin
July 9, 2022

...

Can a kid’s penis really get trapped in swimsuit mesh?

by admin
July 18, 2022

...

Let’s Make Easy Encanto Slime

by admin
July 15, 2022

...

Stroller Vs Baby Carrier Pros And Cons – Baby Journey

by admin
July 15, 2022

...

Copyright © 2022 - ParentingHere - All rights reserved.

No Result
View All Result
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS
  • PREGNANCY
  • BABY CARE
  • TODDLERS
  • TEENS
  • HEALTH CARE
  • ACTIVITIES & CRAFTS
  • Contact
  • About

Copyright © 2022 - ParentingHere - All rights reserved.

We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT