If you’re wondering how long it takes for your body to get rid of excess estrogen, Dr. Lakhani says it depends on how you’re treating the excess estrogen. However, during perimenopause and menopause, Dr. Lakhani points out that estrogen will naturally decrease in the body, and only estrogen will be present after menopause. She also adds, ‘We have estrogen receptors in almost every single cell of our bodies, so when there’s less estrogen to go around, it affects nearly every part of us — from our vulvas and vaginas to our brains, bones, heart, joints, skin, and hair, and everything in between.’