• Home
  • Fair Use Disclaimer
  • Terms and Conditions
  • Social Media Disclaimer
  • Privacy Policy
  • Medical Disclaimer
  • FTC Compliance
  • Earnings Disclaimer
  • DMCA Compliance
  • Copyright Notice
  • Anti-Spam Policy
ParentingHere.com
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS

    Pregnancy Calendar – Week 10

    20 children’s books written by celebrities who have kids

    Pregnancy Calendar – Week 11

    Pregnancy Calendar – Week 12

    Postpartum recovery essentials – Newborn Baby

    I sleep-trained my two-month-old with no tears—here’s what worked

    5 natural energy boosters during pregnancy – Newborn Baby

    How to talk about STEM so your kids will listen

    Lamaze Podcast Gives Tips for Parents on Advancing Labor

  • PREGNANCY

    To My Husband, My Work May Be Different, But I’m Tired Too

    100 Powerful Boy Names – Baby Chick

    Secondary Infertility: What It Is and Its Causes

    It’s Okay to Mourn Your Birth Plan

    The Relationship Between Postpartum Mood Disorders and Sleep

    How to Help the Tired Mom Before She Asks

    How to Create a Calming Corner at Home

    To The Struggling Breastfeeding Mom

    104 Dad Quotes That Will Make You Smile

  • BABY CARE

    What you need to know about lanugo and babies born with hair

    The Bugaboo Butterfly Stroller in Action — The Baby Cubby

    Tea Collection, Herschel Supply Co and Maileg — The Baby Cubby

    The Baby Jogger City Sights Modular Stroller On the Go — The Baby Cubby

    What parents need to know about the updated AAP sleep guidelines

    Breastfeeding in a Bottle — The Baby Cubby

    Celebrating the Fathers in Our Lives — The Baby Cubby

    The UPPAbaby MINU V2 Travel Stroller FULL Review and Demo — The Baby Cubby

    Is My Toddler Ready for a Big Kid Bed? — The Baby Cubby

  • TODDLERS

    How to deal when you hear “I’m telling” more than you’d like

    Why it used to take hours to get my kids to sleep

    18 of the best sandals for kids to rock all summer long

    I saved a drowning toddler—and here’s what I learned about pool safety

    When will the COVID vaccine for kids under 5 be available?

    Should Canadian parents be worried about acute hepatitis in children?

    5 ways to get your kid to play alone

    Fees are dropping! See how much less child care will cost in your city

    15 Simple And Effective Anger Management Activities For Kids

  • TEENS

    When Your Teen Stops Telling You Every Detail of Their Life

    Is Your Teen a Highly Sensitive Person? Here Are a Few Things You Should Know

    It’s Graduation Season and Everyone Is Asking, Where Did the Time Go?

    Where Is the Line Between a Teen Quitting and Stopping an Activity?

    I Hate How Often My Teens Order Out and Eat Out

    10 Ways to Support Your Aspiring Athlete

    Too Old for Camp, Too Young for a Job: Summer Activities for Tweens

    Bad Weather Driving Safety Tips for Teens

    Here Are The Best 34 Dorm Ideas You’ve Never Thought Of

  • HEALTH CARE

    Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

    New funding to help advance scientific understanding of skin disorders in children and young people

    Addressing parents’ hesitancy to vaccinate their children against COVID

    Using air filters at home can reduce negative impacts of air pollution on children’s brain development

    Online classes during school closures may have helped protect adolescents’ mental health

    The impact of drum training on behavior and brain function in autistic adolescents

    Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

    Study finds vaccination hesitancy among parents of children with kidney disease or hypertension

    Childhood bronchitis increases the risk of lung diseases in adult life

  • ACTIVITIES & CRAFTS

    For $295 per night you can live inside this storybook cottage resort in Alberta

    21 Classic and Funny Campfire Songs for Any Camping Trip | MommyPoppins

    Cursive W Worksheets- Free Printable Cursive Practice Sheets For Letter W

    Blippi, Festivals, and More Fun Things To Do in Connecticut This Weekend With Kids | MommyPoppins

    Cursive V Worksheets- Free Printable Cursive Practice Sheets For Letter V |Kids Activities Blog

    Family fun! 6 things to do in New Hampshire with kids

    40 Classic Outdoor Games for Kids: Backyard Games, Playground Games, and More | MommyPoppins

    Cursive U Worksheets- Free Printable Cursive Practice Sheets For Letter U

    The DiscOasis in Central Park Brings Funky Summer Fun to NYC | MommyPoppins

  • Contact
  • About
No Result
View All Result
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS

    Pregnancy Calendar – Week 10

    20 children’s books written by celebrities who have kids

    Pregnancy Calendar – Week 11

    Pregnancy Calendar – Week 12

    Postpartum recovery essentials – Newborn Baby

    I sleep-trained my two-month-old with no tears—here’s what worked

    5 natural energy boosters during pregnancy – Newborn Baby

    How to talk about STEM so your kids will listen

    Lamaze Podcast Gives Tips for Parents on Advancing Labor

  • PREGNANCY

    To My Husband, My Work May Be Different, But I’m Tired Too

    100 Powerful Boy Names – Baby Chick

    Secondary Infertility: What It Is and Its Causes

    It’s Okay to Mourn Your Birth Plan

    The Relationship Between Postpartum Mood Disorders and Sleep

    How to Help the Tired Mom Before She Asks

    How to Create a Calming Corner at Home

    To The Struggling Breastfeeding Mom

    104 Dad Quotes That Will Make You Smile

  • BABY CARE

    What you need to know about lanugo and babies born with hair

    The Bugaboo Butterfly Stroller in Action — The Baby Cubby

    Tea Collection, Herschel Supply Co and Maileg — The Baby Cubby

    The Baby Jogger City Sights Modular Stroller On the Go — The Baby Cubby

    What parents need to know about the updated AAP sleep guidelines

    Breastfeeding in a Bottle — The Baby Cubby

    Celebrating the Fathers in Our Lives — The Baby Cubby

    The UPPAbaby MINU V2 Travel Stroller FULL Review and Demo — The Baby Cubby

    Is My Toddler Ready for a Big Kid Bed? — The Baby Cubby

  • TODDLERS

    How to deal when you hear “I’m telling” more than you’d like

    Why it used to take hours to get my kids to sleep

    18 of the best sandals for kids to rock all summer long

    I saved a drowning toddler—and here’s what I learned about pool safety

    When will the COVID vaccine for kids under 5 be available?

    Should Canadian parents be worried about acute hepatitis in children?

    5 ways to get your kid to play alone

    Fees are dropping! See how much less child care will cost in your city

    15 Simple And Effective Anger Management Activities For Kids

  • TEENS

    When Your Teen Stops Telling You Every Detail of Their Life

    Is Your Teen a Highly Sensitive Person? Here Are a Few Things You Should Know

    It’s Graduation Season and Everyone Is Asking, Where Did the Time Go?

    Where Is the Line Between a Teen Quitting and Stopping an Activity?

    I Hate How Often My Teens Order Out and Eat Out

    10 Ways to Support Your Aspiring Athlete

    Too Old for Camp, Too Young for a Job: Summer Activities for Tweens

    Bad Weather Driving Safety Tips for Teens

    Here Are The Best 34 Dorm Ideas You’ve Never Thought Of

  • HEALTH CARE

    Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

    New funding to help advance scientific understanding of skin disorders in children and young people

    Addressing parents’ hesitancy to vaccinate their children against COVID

    Using air filters at home can reduce negative impacts of air pollution on children’s brain development

    Online classes during school closures may have helped protect adolescents’ mental health

    The impact of drum training on behavior and brain function in autistic adolescents

    Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

    Study finds vaccination hesitancy among parents of children with kidney disease or hypertension

    Childhood bronchitis increases the risk of lung diseases in adult life

  • ACTIVITIES & CRAFTS

    For $295 per night you can live inside this storybook cottage resort in Alberta

    21 Classic and Funny Campfire Songs for Any Camping Trip | MommyPoppins

    Cursive W Worksheets- Free Printable Cursive Practice Sheets For Letter W

    Blippi, Festivals, and More Fun Things To Do in Connecticut This Weekend With Kids | MommyPoppins

    Cursive V Worksheets- Free Printable Cursive Practice Sheets For Letter V |Kids Activities Blog

    Family fun! 6 things to do in New Hampshire with kids

    40 Classic Outdoor Games for Kids: Backyard Games, Playground Games, and More | MommyPoppins

    Cursive U Worksheets- Free Printable Cursive Practice Sheets For Letter U

    The DiscOasis in Central Park Brings Funky Summer Fun to NYC | MommyPoppins

  • Contact
  • About
No Result
View All Result
ParentingHere.com
No Result
View All Result
Home HEALTH CARE

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

by admin
June 23, 2022
in HEALTH CARE



Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision cancer drugs.

Reporting in Nature Medicine, researchers from Dana-Farber/Boston Children’s Cancer and Blood Disorders Center said molecular profiling of solid tumors found clinically significant genetic variations in 298, or 6% of 345 pediatric patients. In 240 patients, the genetic “fingerprint” or pattern of cancer-related changes in the tumor’s DNA could be used to choose a targeted, precision therapy matched to those alterations. Of these patients, 200 were eligible for matched drug therapy.

Targeted therapies were used to treat 29 patients, and 24% of the patients responded to the targeted drugs or experienced a durable clinical benefit. In addition, the molecular profiling – done by a process called next-generation sequencing – clarified the diagnostic classification in 17 patients.

By providing a more accurate diagnosis or identifying a targeted therapy, molecular tumor profiling significantly impacts the care we provide. The result is cancer treatment that is more effective and, in some cases, has fewer side effects.”


Katherine A. Janeway, MD, MMSc, Senior Physician, Dana-Farber / Boston Children’s Cancer and Blood Disorders Center Director, Clinical Genomics, Dana-Farber Cancer Institute and Associate Professor of Pediatrics, Harvard Medical School

The ongoing study, known as the GAIN/iCat2, is being carried out at 12 centers in the United States to evaluate the clinical impact of genomic sequencing of pediatric solid tumors, which is much less commonly performed than in adult patients with solid tumors. In adults, tumor profiling is recommended in national practice guidelines as an aid to diagnosis and treatment. But there are no such guidelines or insurance coverage decisions for using tumor profiling in pediatric solid malignancies and few clinical trials of tumor profiling include young people with cancer.

Pediatric solid tumors are much rarer than they are in adults, and large studies of genetic alterations are difficult to carry out. In fact, there were 59 different tumor types affecting the patients in this study and some of the cancers are so rare that they affected just one patient. Pediatric tumors also tend to have fewer gene mutations than those in adults, so there are fewer targets for drugs to attack – and fewer drugs available to target them. The net result is that most solid tumors in children are treated with standard chemotherapy or radiation rather than precision drug agents.

The current study is a prospective observational cohort study led by Janeway and Alanna J. Church, MD, associate director for Molecular Pediatric Pathology at Boston Children’s Hospital and Katherine A. Janeway, MD, MMSc, director of Clinical Genomics at Dana-Farber and Boston Children’s. Janeway has been working to bring personalized, molecularly targeted treatments to children with cancer. The results of Janeway’s first study, called Individualized Cancer Therapy (iCat), were published in 2016 and showed that bringing clinical genomic sequencing to pediatric oncology practice is feasible. Janeway and colleagues are now conducting a follow-up study, the Genomic Assessment Improves Novel Therapy (GAIN) Consortium, iCat2 study.

The study participants were patients with relapsed/refractory or high-risk non-brain tumors at age 30 or younger; the mean age at diagnosis was 12 years. Researchers performed targeted DNA next-generation sequencing with OncoPanel testing on one or more tumor samples from each patient, with some samples subjected to RNA sequencing as well. Based on the analysis, a comprehensive report is created and sent to the referring physician. This allows the physician to develop a plan for the patient that takes into account the genetic changes detected in their tumors that are associated with matched drugs that have yielded success either in the laboratory or in the clinic in treating patients with such tumors. The study tracks each patient to determine the impact of the treatment plan on the patient’s outcome. The primary goal of the study is to observe if the tumor profiling and matched targeted drug treatment affects overall survival.

Recommendations for molecularly targeted therapy (MTT) based on data from the previous iCat study were returned to 240 of the 345 patients whose tumors had at least one gene variant. Of these, 200 patients were eligible for assessment of receipt and response to MTT, being alive and having complete follow-up data. Ninety-six of the patients would not have been expected to consider targeted therapy because they were receiving frontline therapy, had no cancer-directed systemic therapy during the follow-up period, or no matched targeted drugs were available.

Seven patient who received matched targeted therapy had measurable significant responses to the therapy. In six of those tumors the therapies were matched to a gene fusion. Fusion genes are formed within a cell when a piece of one chromosome breaks off and attaches to another chromosome, causing broken DNA segments to fuse together to form an entirely new gene. Some of these genes produce fusion proteins that can cause cells to grow uncontrollably and form tumors.

“Gene fusions are very important in pediatric tumors,” says Church. “It’s an exciting time because there are so many new drugs that can target these fusions and we have new tests that can reliably detect them.”

Church and Janeway hope their work will help make genomic profiling standard of care for new or relapsed pediatric solid tumors, reimbursable by insurance -; just as it is for adults.

“We know there are patients who aren’t getting access to these tests because they are not being reimbursed consistently,” says Church. “We want to broaden access to molecular profiling for every child with a solid tumor.”

Source:

Dana-Farber Cancer Institute



Original Source Link

Previous Post

20 children’s books written by celebrities who have kids

Next Post

For $295 per night you can live inside this storybook cottage resort in Alberta

Related Posts

HEALTH CARE

New funding to help advance scientific understanding of skin disorders in children and young people

June 23, 2022
HEALTH CARE

Addressing parents’ hesitancy to vaccinate their children against COVID

June 23, 2022
HEALTH CARE

Using air filters at home can reduce negative impacts of air pollution on children’s brain development

June 23, 2022
HEALTH CARE

Online classes during school closures may have helped protect adolescents’ mental health

June 22, 2022
HEALTH CARE

The impact of drum training on behavior and brain function in autistic adolescents

June 22, 2022
HEALTH CARE

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

June 22, 2022
Next Post

For $295 per night you can live inside this storybook cottage resort in Alberta

When Your Teen Stops Telling You Every Detail of Their Life

What you need to know about lanugo and babies born with hair

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Recommended

Co-development of three systems linked with baby’s respiratory health

6 days ago

25 Ways for Dads to Connect with Kids

5 days ago

The DiscOasis in Central Park Brings Funky Summer Fun to NYC | MommyPoppins

2 days ago

To The Struggling Breastfeeding Mom

4 days ago

New combination of drugs effective against T-cell acute lymphoblastic leukemia

3 days ago

40 Classic Outdoor Games for Kids: Backyard Games, Playground Games, and More | MommyPoppins

2 days ago

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

6 hours ago

Categories

  • ACTIVITIES & CRAFTS (200)
  • BABY CARE (110)
  • HEALTH CARE (166)
  • PARENTING TIPS (185)
  • PREGNANCY (102)
  • TEENS (163)
  • TODDLERS (31)

Popular Posts

127+ Cute Nicknames for Boys

3 weeks ago

Top Travel Prams 2022 – Newborn Baby

2 weeks ago

How to Talk to Teenagers About Current Events

4 weeks ago

Importance of knowing correct paediatric first aid – Newborn Baby

1 month ago

Writing is Better Than Typing For Students

3 weeks ago

Fabulous first birthday gifts – Today’s Parent

5 days ago

Cursive P Worksheets- Free Printable Cursive Practice Sheets For Letter P Kids Activities Blog

7 days ago

Archives

  • June 2022 (373)
  • May 2022 (415)
  • April 2022 (53)
  • March 2022 (92)
  • February 2022 (24)

Reader's Choices

4 TRENDY AND MODERN HAIRSTYLES FOR WOMEN IN 2021

by admin
May 30, 2022

...

Eyes may be able to signal ASD and ADHD

by admin
June 18, 2022

...

Stanford researcher outlines pollution and climate change threats to children’s health

by admin
June 17, 2022

...

Easy loot bag ideas that kids love

by admin
June 17, 2022

...

Editor's Picks

5 Meaningful Last-Minute Father’s Day Gifts for New Dads

by admin
June 21, 2022

...

Breastfeeding in a Bottle — The Baby Cubby

by admin
June 20, 2022

...

20 children’s books written by celebrities who have kids

by admin
June 23, 2022

...

10 Ways to Support Your Aspiring Athlete

by admin
June 22, 2022

...

Popular Posts

Pregnancy Calendar – Week 6

by admin
June 20, 2022

...

How to Talk to Our Kids About Scary World Events — The Baby Cubby

by admin
June 3, 2022

...

Tribeca Film Festival and 22 More Things To Do in NYC This Weekend With Kids | MommyPoppins

by admin
June 8, 2022

...

Asymptomatic COVID-19 during pregnancy could have potential long-term consequences for the baby

by admin
May 31, 2022

...

Copyright © 2022 - ParentingHere - All rights reserved.

No Result
View All Result
  • Home
  • Shop
    • Baby Bouncers
    • Baby Car Seats
    • Baby Clothes
    • Baby Jumpers
    • Baby Toys
    • Baby Walkers
    • Boys Clothing
    • Child Booster Car Seats
    • Child Carriers
    • Childrens Toys
    • Craft Supplies
    • Cribs
    • Funny Parenting T Shirts
    • Girls Clothing
    • Parenting Books
    • Strollers
  • PARENTING TIPS
  • PREGNANCY
  • BABY CARE
  • TODDLERS
  • TEENS
  • HEALTH CARE
  • ACTIVITIES & CRAFTS
  • Contact
  • About

Copyright © 2022 - ParentingHere - All rights reserved.

We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checkbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT